Acetylcholinesterase: diffusional encounter rate constants for dumbbell models of ligand
نویسندگان
چکیده
منابع مشابه
Brownian dynamics simulation of protein-protein diffusional encounter.
Protein association events are ubiquitous in biological systems. Some protein associations and subsequent responses are diffusion controlled in vivo. Hence, it is important to be able to compute bimolecular diffusional association rates for proteins. The Brownian dynamics simulation methodology may be used to simulate protein-protein encounter, compute association rates, and examine their depen...
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Determination of dissociation constants and specific rate constants of enzyme-substrate (or protein-ligand) interactions from rapid reaction kinetic data.
The increasing availability of instruments capable of following absorbance or fluorescence changes in the millisecond time range has led in recent years to a large number of studies of ligandprotein interactions. Of particular interest to the enzymologist are cases where partial reactions in the catalytic cycle may be followed. For example, the reaction of a dehydrogenase with reduced pyridine ...
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The increasing availability of instruments capable of following absorbance or fluorescence changes in the millisecond time range has led in recent years to a large number of studies of ligandprotein interactions. Of particular interest to the enzymologist are cases where partial reactions in the catalytic cycle may be followed. For example, the reaction of a dehydrogenase with reduced pyridine ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1995
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(95)80159-1